The Effect of Diclofenac Sodium on the Renal Parenchyma During Complete Unilateral Ureteral Obstruction of the Rats

Obstrution of the urinary tract is a potential cause of renal failure. Acute unilateral obstruction of the kidney is associated with an increase in pelvic pressure followed by a decrease in ipsilateral renal blood flow (1). Concomitantly with these pressure changes the synthesis of renal vasoactive hormones is changed. There are different opinions about the effects of prostaglandins (PGs) on renal functions and the administration of PG synthesis inhibitors during acute urinary obstruction (AUO) (1-5). On the other hand, the Iymphocytic infiltration and infection may occur in the renal parenchyma because of the decreased renal blood flow during AUO. Therefore, it is expected that prophylactic antibiotics are useful during the ureteral obstruction. This experimental study was planned to investigate the effects of diclofenac sodium (DS) which is a PGs and thromboxanes (TXs) synthesis inhibitor on both renal parenchyma during complete unilateral ureteral obstruction.